Article
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
Bone - 1 Feb 2010
Tang Nelson L S, Liao Chen Di, Ching Jasmine K L, Suen Eddie W C, Chan Iris H S, Orwoll Eric, Ho Suzanne C, Chan Frank W K, Kwok Anthony W L, Kwok Timothy, Woo Jean, Leung Ping Chung
Abstract excerpt
BACKGROUND: Osteoporosis is a common condition among elderly. Genetic mapping studies repeatedly located the distal short arms of X-chromosome as the quantitative trait loci (QTL) for BMD in mice. Fine mapping of a syntenic segment on Xp22 in a Caucasian female population suggested a moderate association between lumbar spine (LS) BMD and 2 intronic SNPs in the Pirin (PIR) gene, which encodes an iron-binding...
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