Article
Nociceptive phenotype of dorsal root ganglia neurons innervating the subchondral bone in rat knee joints.
European journal of pain (London, England) - 1 Feb 2014
Aso K, Ikeuchi M, Izumi M, Sugimura N, Kato T, Ushida T, Tani T
Abstract excerpt
BACKGROUND: The subchondral bone of the distal femur is a source of pain caused by osteoarthritis (OA) or spontaneous osteonecrosis of the knee. However, nociceptive phenotype of dorsal root ganglia (DRG) neurons innervating the subchondral bone in rat knee joints has not been clarified. METHODS: Retrograde labelling was used to identify afferents innervating the subchondral bone of the distal femur and the knee...
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