Article
FGF1 nuclear translocation is required for both its neurotrophic activity and its p53-dependent apoptosis protection.
Biochimica et biophysica acta - 1 Nov 2009
Rodriguez-Enfedaque Aida, Bouleau Sylvina, Laurent Maryvonne, Courtois Yves, Mignotte Bernard, Vayssière Jean-Luc, Renaud Flore
Abstract excerpt
Fibroblast growth factor 1 (FGF1) is a differentiation and survival factor for neuronal cells both in vitro and in vivo. FGF1 activities can be mediated not only by paracrine and autocrine pathways involving FGF receptors but also by an intracrine pathway, which is an underestimated mode of actio...
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