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Evaluation of variants in the CHEK2, BRIP1 and PALB2 genes in an Irish breast cancer cohort.

Breast cancer research and treatment - 1 May 2010

McInerney N M, Miller N, Rowan A, Colleran G, Barclay E, Curran C, Kerin M J, Tomlinson I P, Sawyer E

Abstract excerpt

It has been proposed that rare variants within the double strand break repair genes CHEK2, BRIP1 and PALB2 predispose to breast cancer. The aim of this study was to evaluate the prevalence of these variants in an Irish breast cancer cohort and determine their contribution to the development of breast cancer in the west of Ireland. We evaluated the presence of CHEK2_1100delC variant in 903 breast cancer cases and...

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Identifiers

PMID: 19763819
DOI: 10.1007/s10549-009-0540-9

Genes

BRIP1
PALB2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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