Article
DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis.
European archives of psychiatry and clinical neuroscience - 1 Apr 2010
Mössner Rainald, Schuhmacher Anna, Wagner Michael, Quednow Boris B, Frommann Ingo, Kühn Kai-Uwe, Schwab Sibylle G, Rietschel Marcella, Falkai Peter, Wölwer Wolfgang, Ruhrmann Stephan, Bechdolf Andreas, Gaebel Wolfgang, Klosterkötter Joachim, Maier Wolfgang
Abstract excerpt
The genetic factors determining the progression of prodromal syndromes to first episode schizophrenia have remained enigmatic to date. In a unique prospective multicentre trial, we assessed whether variants at the D-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis. Young subjects with a prodromal syndrome were observed prospectively for up to 2 years to assess the incidence of...
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