Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors.

Oncogene - 31 Jul 2008

Perotti D, Gamba B, Sardella M, Spreafico F, Terenziani M, Collini P, Pession A, Nantron M, Fossati-Bellani F, Radice P

Abstract excerpt

For many years the precise genetic etiology of the majority of Wilms' tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms' tumors. Moreover, in female cases, the somatically inactivated alleles were found to invariantly derive from the active chromosome X. Consequently, WTX has been proposed as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Deletion

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Tumor Suppressor Proteins

Share to Wilms Tumor

Source

Identifiers

PMID: 18391980
DOI: 10.1038/onc.2008.93

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors.PMID 18391980Read ↗

<i>WTX</i> inactivation is a frequent, but late event in Wilms tumors without apparent clinical impactSemantic proximity Read ↗

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.Semantic proximity Read ↗

Identification and analysis of mutations in WTX and WT1 genes in peripheral blood and tumor tissue of children with Wilms' tumor.Semantic proximity Read ↗

Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors.Semantic proximity Read ↗

Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation.Semantic proximity Read ↗

Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor.Semantic proximity Read ↗

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome.Semantic proximity Read ↗

A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor.Semantic proximity Read ↗

The genomic organization and expression of the WT1 gene.Semantic proximity Read ↗

Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor.Semantic proximity Read ↗

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis.Semantic proximity Read ↗

The General Expression Analysis of WTX Gene in Normal and Cancer Tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.