Impact of genotype misclassification on genetic association estimates and the bayesian adjustment.

Abstract excerpt

Genotypes of single nucleotide polymorphisms are subject to misclassification. If ignored, such misclassification can seriously distort the estimated genotype effects on the disease or outcome of interest. Validation data (gold standard or replicated surrogates) are required to assess the degree of misclassification and make adjustments. In practice, gold standard measurements may be unavailable or impractical....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bayes Theorem
• Share to Bias
• Share to Genome-Wide Association Study