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Article

Naturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains.

The Journal of biological chemistry - 20 Nov 2009

Ma Liang, Xu Meixiang, Forman Julia R, Clarke Jane, Oberhauser Andres F

Abstract excerpt

Mutations in polycystin-1 (PC1) can cause autosomal dominant polycystic kidney disease, which is a leading cause of renal failure. The available evidence suggests that PC1 acts as a mechanosensor, receiving signals from the primary cilia, neighboring cells, and extracellular matrix. PC1 is a larg...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19759016
DOI: 10.1074/jbc.M109.021832
PMCID: PMC2781709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19759016-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Naturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains.PMID 19759016Read ↗

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