Article
The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.
The EMBO journal - 15 Jan 1999
Bycroft M, Bateman A, Clarke J, Hamill S J, Sandford R, Thomas R L, Chothia C
Abstract excerpt
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of mutations in the PKD1 gene. The PKD1 gene codes for a large cell-surface glycoprotein, polycystin-1, of unknown function, which, based on its predicted domain structure, may be involved in protein-protein and pro...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Conserved Sequence
- DNA Primers
- Escherichia coli
- Fishes, Poisonous
- Humans
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Polycystic Kidney, Autosomal Dominant
- Protein Conformation
- Protein Structure, Secondary
- Proteins
- Recombinant Proteins
- TRPP Cation Channels