Article
The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.
The EMBO journal - 15 Jan 1999
Bycroft M, Bateman A, Clarke J, Hamill S J, Sandford R, Thomas R L, Chothia C
Abstract excerpt
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of mutations in the PKD1 gene. The PKD1 gene codes for a large cell-surface glycoprotein, polycystin-1, of unknown function, which, based on its predicted domain structure, may be involved in protein-protein and protein-carbohydrate interactions. Approximately 30% of polycystin-1 consists of 16 copies of a novel protein module...
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