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Article

Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations.

BMC bioinformatics - 27 Aug 2009

Reumers Joke, Schymkowitz Joost, Rousseau Fréderic

Abstract excerpt

BACKGROUND: Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and residue burial can be used to distinguish neutral variations and disease associated mutations. RESULTS: We have investigated 39 structural properties on a set of SNPs and disease mutations from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19758473
DOI: 10.1186/1471-2105-10-S8-S9
PMCID: PMC2745591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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