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Article

Robust classification of protein variation using structural modelling and large-scale data integration.

Nucleic acids research - 7 Apr 2016

Baugh Evan H, Simmons-Edler Riley, Müller Christian L, Alford Rebecca F, Volfovsky Natalia, Lash Alex E, Bonneau Richard

Abstract excerpt

Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness and frequently use only sequence-based or structure-based information. We present VIPUR, a computational framework that seamlessly integrates sequence analysis and structural modelling (using the Rosetta protein modelling suite) to identify and interpret...

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Identifiers

PMID: 26926108
DOI: 10.1093/nar/gkw120
PMCID: PMC4824117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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