Article

Robust Classification of Protein Variation Using Structural Modeling and Large-Scale Data Integration

2015-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness and frequently use only sequence-based or structure-based information. We present VIPUR, a computational framework that seamlessly integrates sequence analysis and structural modeling (using the Rosetta protein modeling suite) to identify a...

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Literature Corpus work: bde00d94-0e81-5e8a-b569-143f022a6077
DOI: 10.1101/029041

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