Article
An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D.
BMC bioinformatics - 27 Aug 2009
Izarzugaza Jose M G, Baresic Anja, McMillan Lisa E M, Yeats Corin, Clegg Andrew B, Orengo Christine A, Martin Andrew C R, Valencia Alfonso
Abstract excerpt
BACKGROUND: The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stability. In order better to understand the mechanisms behind known mutant phenotypes, and predict the effects of novel variations, biologists need tools to gauge the impacts of DNA mutations in terms...
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