RNA interference‐mediated knock‐down of Bla g 1 in the German cockroach, Blattella germanica L., implicates this allergen‐encoding gene in digestion and nutrient absorption

Abstract excerpt

We used RNA interference (RNAi) to silence the expression of a gene encoding Bla g 1, a human allergen produced by the German cockroach, Blattella germanica L., to study its function in cockroach physiology. Females injected with 1 microg of double-stranded RNA contained 64% less Bla g 1 protein and Bla g 1 mRNA abundance was reduced by 91.4% compared to sham-injected females. Bla g 1 knockdown slowed the pace of...

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