Article
Genetic susceptibility loci in rheumatoid arthritis establish transcriptional regulatory networks with other genes.
Annals of the New York Academy of Sciences - 1 Sept 2009
Silva Guilherme Liberato, Junta Cristina Moraes, Sakamoto-Hojo Elza Tiemi, Donadi Eduardo Antonio, Louzada-Junior Paulo, Passos Geraldo A S
Abstract excerpt
Linkage studies have identified the human leukocyte antigen (HLA)-DRB1 as a putative rheumatoid arthritis (RA) susceptibility locus (SL). Nevertheless, it was estimated that its contribution was partial, suggesting that other non-HLA genes may play a role in RA susceptibility. To test this hypothesis, we conducted microarray transcription profiling of peripheral blood mononuclear cells in 15 RA patients and...
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