Article
Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.
PloS one - 16 Sept 2009
Lewis David J M, Huo Zhiming, Barnett Susan, Kromann Ingrid, Giemza Rafaela, Galiza Eva, Woodrow Maria, Thierry-Carstensen Birgit, Andersen Peter, Novicki Deborah, Del Giudice Giuseppe, Rappuoli Rino
Abstract excerpt
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT) adjuvant. The individual component(s) responsible for paralysis were not identified, and the vaccine was withdrawn. METHODOLOGY/PRINCIPAL FINDINGS: Subjects...
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