Proteoglycan and Collagen Accumulation by Passaged Chondrocytes Can Be Enhanced Through Side-by-Side Culture with Primary Chondrocytes

Abstract excerpt

Identifying a source of sufficient numbers of chondrocytes for cartilage tissue engineering is a major factor limiting its use clinically. Previously we demonstrated that combined coculture of passaged dedifferentiated articular chondrocytes with primary bovine chondrocytes will induce their redifferentiation. In this study we determine whether these two cell types have to be in contact, whether human...

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