Article
Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus.
The pharmacogenomics journal - 1 Apr 2010
Kurzawski Mateusz, Dziewanowski Krzysztof, Kedzierska Karolina, Gornik Wanda, Banas Anna, Drozdzik Marek
Abstract excerpt
New-onset, posttransplant diabetes mellitus (PTDM) has a high incidence after kidney transplantation in patients medicated with tacrolimus, and may adversely affect the patient and graft survival. The pathophysiology of PTDM closely mimics that of type II diabetes mellitus (T2DM). One of possible genetic factors predisposing to PTDM might be polymorphism in calpain-10 gene (CAPN10), previously associated with...
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