Article
Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus.
Pharmacological reports : PR - 1 Jan 2011
Kurzawski Mateusz, Dziewanowski Krzysztof, Kędzierska Karolina, Wajda Anna, Lapczuk Joanna, Droździk Marek
Abstract excerpt
New onset posttransplant diabetes mellitus (PTDM) has a high incidence after kidney transplantation in patients medicated with tacrolimus. PTDM can adversely affect patient and graft survival. The pathophysiology of PTDM closely mimics type 2 diabetes mellitus (T2DM). One of the possible genetic factors predisposing individuals to PTDM might be a polymorphism in the transcription factor 7-like 2 gene (TCF7L2)....
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