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Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Oct 2009

Schurek Kristen N, Sampaio Jorge L M, Kiffer Carlos R V, Sinto Sumiko, Mendes Caio M F, Hancock Robert E W

Abstract excerpt

During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. Possible mechanisms underlying this phenotype were investigated. The effects of various concentrations of polymyxin B on growth, the...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Cystic Fibrosis
Drug Resistance, Multiple, Bacterial
Genotype
Microbial Sensitivity Tests
Polymyxin B
Promoter Regions, Genetic
Pseudomonas aeruginosa

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PMID: 19635950
DOI: 10.1128/AAC.01267-08
PMCID: PMC2764176

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