Article
Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Oct 2009
Schurek Kristen N, Sampaio Jorge L M, Kiffer Carlos R V, Sinto Sumiko, Mendes Caio M F, Hancock Robert E W
Abstract excerpt
During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. Possible mechanisms underlying this phenotype were investigated. The effects of various concentrations of polymyxin B on growth, the...
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