Article
Genetic evidence from 7 families that the apolipoprotein B gene is not involved in familial combined hyperlipidemia.
Atherosclerosis - 1 Jul 1990
Rauh G, Schuster H, Müller B, Schewe S, Keller C, Wolfram G, Zöllner N
Abstract excerpt
Familial combined hyperlipidemia (FCHL) is the most common genetic form of hyperlipidemia in which affected individuals manifest multiple lipoprotein phenotypes. Although the molecular defect is still unknown, several kinetic studies have demonstrated increased turnover rates of apolipoprotein B (apo B) in patients with FCHL, irrespective of their lipoprotein phenotype. Using 3 restriction fragment length...
Topics
- Adult
- Aged
- Alleles
- Apolipoproteins B
- Cholesterol
- Cholesterol, LDL
- Female
- Genotype
- Humans
- Hyperlipidemia, Familial Combined
- Male
- Middle Aged