Article
The effect of replication initiation on gene amplification in the rDNA and its relationship to aging.
Molecular cell - 11 Sept 2009
Ganley Austen R D, Ide Satoru, Saka Kimiko, Kobayashi Takehiko
Abstract excerpt
In eukaryotes, the ribosomal DNA (rDNA) consists of long tandem repeat arrays. These repeated genes are unstable because homologous recombination between them results in copy number loss. To maintain high copy numbers, yeast has an amplification system that works through a pathway involving the replication fork barrier site and unequal sister chromatid recombination. In this study, we show that an active...
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