Article
Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics.
Science (New York, N.Y.) - 11 Sept 2009
Gusarov Ivan, Shatalin Konstantin, Starodubtseva Marina, Nudler Evgeny
Abstract excerpt
Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo. However, the physiological role of bNOS remains largely unknown. We show that NO generated by bNOS increases the resistance of bacteria to a broad spectrum of antibiotics, enabling the bacteria to survive and share habitats with antibiotic-producing...
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