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Article

NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response.

Reviews in immunogenetics - 1 Jan 2000

Karupiah G, Hunt N H, King N J, Chaudhri G

Abstract excerpt

Using highly conserved, complex enzyme systems, leukocytes utilize the toxic nature of free radical intermediates, derived from oxygen and nitrogen, to control microbial pathogens as part of the innate immune response. Upon activation, NADPH oxidase generates superoxide anion radicals, which in turn give rise to further reactive oxygen intermediates. Similarly, activated nitric oxide synthase 2 catalyses the...

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PMID: 11256747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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