Article
Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007
Hyduke Daniel R, Jarboe Laura R, Tran Linh M, Chou Katherine J Y, Liao James C
Abstract excerpt
Nitric oxide (NO) is used by mammalian immune systems to counter microbial invasions and is produced by bacteria during denitrification. As a defense, microorganisms possess a complex network to cope with NO. Here we report a combined transcriptomic, chemical, and phenotypic approach to identify direct NO targets and construct the biochemical response network. In particular, network component analysis was used to...
Topics
- Adaptation, Physiological
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Gene Regulatory Networks
- Hydro-Lyases
- Iron-Sulfur Proteins
- Models, Biological
- Nitric Oxide
- Phenotype
- Transcription Factors