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Article

Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Hyduke Daniel R, Jarboe Laura R, Tran Linh M, Chou Katherine J Y, Liao James C

Abstract excerpt

Nitric oxide (NO) is used by mammalian immune systems to counter microbial invasions and is produced by bacteria during denitrification. As a defense, microorganisms possess a complex network to cope with NO. Here we report a combined transcriptomic, chemical, and phenotypic approach to identify direct NO targets and construct the biochemical response network. In particular, network component analysis was used to...

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Identifiers

PMID: 17494765
DOI: 10.1073/pnas.0610888104
PMCID: PMC1895976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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