Article
Architectural limits on split genes.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 1996
Sterner D A, Carlo T, Berget S M
Abstract excerpt
Exon/intron architecture varies across the eukaryotic kingdom with large introns and small exons the rule in vertebrates and the opposite in lower eukaryotes. To investigate the relationship between exon and intron size in pre-mRNA processing, internally expanded exons were placed in vertebrate genes with small and large introns. Both exon and intron size influenced splicing phenotype. Intron size dictated if...
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