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Article

Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model

19 Jan 2021

Abstract excerpt

BACKGROUND: Knowledge regarding the pathogenesis of osteoarthritis (OA) is very limited. Previous studies have shown that matrix metalloproteinase (MMP) 8 and MMP9 were upregulated in patients with diabetic OA. However, their regulatory functions and mechanisms in diabetic OA are not fully understood. METHODS: Diabetic OA rats were constructed using a high-fat diet combined with streptozotocin (STZ) induction....

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PMID: 33468174
DOI: 10.1186/s13018-021-02208-9

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