Acetyl-CoA carboxylase mRNA species with or without inhibitory coding sequence for Ser-1200 phosphorylation.

Abstract excerpt

Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in the biogenesis of long chain fatty acids. The phosphorylation of the Ser-1200 residue by cyclic AMP-dependent protein kinase transforms ACC from a citrate-independent form to a citrate-dependent form (10, 16). We have isolated ACC cDNA clones with and without 24 bases which code for 8 additional amino acids located 4 residues upstream to the Ser-1200....

Topics

• Acetyl-CoA Carboxylase
• Adipose Tissue
• Amino Acid Sequence
• Animals
• Base Sequence
• Cloning, Molecular
• Codon
• DNA
• Dietary Fats
• Female
• Gene Expression Regulation, Enzymologic