Article
NOD2 regulates hematopoietic cell function during graft-versus-host disease.
The Journal of experimental medicine - 28 Sept 2009
Penack Olaf, Smith Odette M, Cunningham-Bussel Amy, Liu Xin, Rao Uttam, Yim Nury, Na Il-Kang, Holland Amanda M, Ghosh Arnab, Lu Sydney X, Jenq Robert R, Liu Chen, Murphy George F, Brandl Katharina, van den Brink Marcel R M
Abstract excerpt
Nucleotide-binding oligomerization domain 2 (NOD2) polymorphisms are independent risk factors for Crohn's disease and graft-versus-host disease (GVHD). In Crohn's disease, the proinflammatory state resulting from NOD2 mutations have been associated with a loss of antibacterial function of enterocytes such as paneth cells. NOD2 has not been studied in experimental allogeneic bone marrow transplantation (allo-BMT)....
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