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Article

A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses.

British journal of haematology - 1 Nov 2009

Suessmuth Yvonne, Elliott Joanne, Percy Melanie J, Inami Mitsuharu, Attal Hila, Harrison Claire N, Inokuchi Koiti, McMullin Mary-Frances, Johnston James A

Abstract excerpt

Recently several different JAK2 exon12 mutations have been identified in V617F negative polycythaemia vera (PV) or idiopathic erythrocytosis (IE) patients. The patients present with erythrocytosis, ligand-independent cell growth and low serum erythropoietin (EPO) levels. Within this group, a dele...

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Source

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Identifiers

PMID: 19735488
DOI: 10.1111/j.1365-2141.2009.07860.x
PMCID: PMC2838228

Genes

JAK2
SOCS3
EPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19735488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses.PMID 19735488Read ↗

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