Article
Differential regulation of SOCS genes in normal and transformed erythroid cells.
Oncogene - 22 May 2003
Sarna Mohinder K, Ingley Evan, Busfield Samantha J, Cull Vanessa S, Lepere Winald, McCarthy David J, Wright Michael J, Palmer Gene A, Chappell David, Sayer Melissa S, Alexander Warren S, Hilton Douglas J, Starr Robyn, Watowich Stephanie S, Bittorf Thomas, Klinken S Peter, Tilbrook Peta A
Abstract excerpt
The SOCS family of genes are negative regulators of cytokine signalling with SOCS-1 displaying tumor suppressor activity. SOCS-1, CIS and SOCS-3 have been implicated in the regulation of red blood cell production. In this study, a detailed examination was conducted on the expression patterns of these three SOCS family members in normal erythroid progenitors and a panel of erythroleukemic cell lines. Unexpectedly,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.