Article
Polycythemia vera and its molecular basis: an update.
Best practice & research. Clinical haematology - 1 Jan 2006
Chen George, Prchal Josef T
Abstract excerpt
The molecular basis of polycythemia vera is discussed in the context of the JAK2 V617F mutation, in our view the most important advance in understanding the pathogenesis of polycythemia vera. This chapter discusses the nature of the JAK2 V617F mutation including the studies demonstrating its role in erythropoietin independence and hypersensitivity and endogenous erythroid colony formation. The evolving evidence...
Topics
- Humans
- Janus Kinase 2
- Mutation
- Polycythemia Vera
- Protein Tyrosine Phosphatases
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Suppressor of Cytokine Signaling 3 Protein
- Suppressor of Cytokine Signaling Proteins