Article
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
Human molecular genetics - 1 Jul 2010
Qi Lu, Cornelis Marilyn C, Kraft Peter, Stanya Kristopher J, Linda Kao W H, Pankow James S, Dupuis Josée, Florez Jose C, Fox Caroline S, Paré Guillaume, Sun Qi, Girman Cynthia J, Laurie Cathy C, Mirel Daniel B, Manolio Teri A, Chasman Daniel I, Boerwinkle Eric, Ridker Paul M, Hunter David J, Meigs James B, Lee Chih-Hao, Hu Frank B, van Dam Rob M
Abstract excerpt
To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24,...
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