Article
Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology.
Biochemical pharmacology - 15 Feb 2011
Petrie John R, Pearson Ewan R, Sutherland Calum
Abstract excerpt
The rapid rise in prevalence of type 2 diabetes mellitus (T2DM) has been driven by changes in environmental factors - primarily increased caloric intake and reduced energy expenditure - resulting in reduced whole body insulin sensitivity (often termed insulin resistance). Insulin resistance has been proposed to be a major driver of progression to T2DM. However, of 38 individual susceptibility loci for T2DM...
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