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Article

Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities.

Blood - 12 Nov 2009

Mottok Anja, Renné Christoph, Seifert Marc, Oppermann Elsie, Bechstein Wolf, Hansmann Martin-Leo, Küppers Ralf, Bräuninger Andreas

Abstract excerpt

STATs are constitutively activated in several malignancies. In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity. Based on indications that the SOCS1 mutations are cause...

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Topics

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Share to Cytokine Signaling Pathways and Interactions
Share to SOCS1 gene
Share to Lymphoma, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymerase Chain Reaction

Share to Somatic Hypermutation, Immunoglobulin

Share to Suppressor of Cytokine Signaling 1 Protein

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Source

Identifiers

PMID: 19734449
DOI: 10.1182/blood-2009-06-225839

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19734449-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities.PMID 19734449Read ↗

Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6.Semantic proximity Read ↗

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.Semantic proximity Read ↗

SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients.Semantic proximity Read ↗

[SOCSJ gene mutations in patients with diffuse large B-cell lymphoma].Semantic proximity Read ↗

[Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation].Semantic proximity Read ↗

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.Semantic proximity Read ↗

Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.Semantic proximity Read ↗

[Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].Semantic proximity Read ↗

Gene methylation and silencing of <i><scp>SOCS</scp>3</i> in mantle cell lymphomaSemantic proximity Read ↗

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Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.Semantic proximity Read ↗

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