Article
Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.
Blood - 6 Aug 2009
Ritz Olga, Guiter Chrystelle, Castellano Flavia, Dorsch Karola, Melzner Julia, Jais Jean-Philippe, Dubois Gwendoline, Gaulard Philippe, Möller Peter, Leroy Karen
Abstract excerpt
Primary mediastinal B-cell lymphoma (PMBL) is a separate entity of aggressive B-cell lymphoma, characterized by a constitutive activation of janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, also observed in Hodgkin lymphoma. Although many cancers exhibit constitutive JAK-STAT pathway activation, mutations of STAT genes have not been reported in neoplasms. Here, we show...
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