Genetic epidemiology of differences in low-density lipoprotein (LDL) cholesterol concentration: possible involvement of variation at the apolipoprotein B gene locus in LDL kinetics.

Abstract excerpt

Circulating levels of low-density lipoprotein (LDL) vary considerably within and between populations, paralleled by differing coronary heart disease (CHD) mortality rates. We have previously shown that variation in the apolipoprotein (apo) B gene as associated with certain restriction fragment length polymorphisms (RFLPs) influences the metabolism of LDL in the U.K. population. To investigate a possible genetic...

Topics

• Adult
• Africa
• Apolipoproteins B
• Blotting, Southern
• Cholesterol, LDL
• Chromosome Mapping
• Female
• Finland
• Genetic Variation
• Humans
• Italy