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Article

Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease.

Lancet (London, England) - 1 Jan 2000

Rajput-Williams J, Knott T J, Wallis S C, Sweetnam P, Yarnell J, Cox N, Bell G I, Miller N E, Scott J

Abstract excerpt

A random sample of 290 white men was examined for association between restriction fragment length polymorphism (RFLP) haplotypes (closely linked RFLPs on a single chromosome) of the apolipoprotein-B gene and serum levels of cholesterol, triglyceride, and high-density lipoprotein, obesity, smoking, alcohol consumption, and coronary heart disease. Haplotype or single RFLP frequencies differed significantly for...

Topics

Aged
Alleles
Apolipoproteins B
Cholesterol
Coronary Disease
Genotype
Haplotypes
Humans
Male
Middle Aged
Obesity
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 2904569
DOI: 10.1016/s0140-6736(88)90930-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2904569-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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