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Article

Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.

The Journal of physiology - 1 Jun 2018

Held Katharina, Gruss Fabian, Aloi Vincenzo Davide, Janssens Annelies, Ulens Chris, Voets Thomas, Vriens Joris

Abstract excerpt

KEY POINTS: Mutagenesis at positively charged amino acids (arginines and lysines) (R1-R4) in the voltage-sensor domain (transmembrane segment (S) 4) of voltage-gated Na+ , K+ and Ca2+ channels can lead to an alternative ion permeation pathway distinct from the central pore. Recently, a non-canonical ion permeation pathway was described in TRPM3, a member of the transient receptor potential (TRP) superfamily. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29604058
DOI: 10.1113/JP274124
PMCID: PMC6002228

Genes

TRPM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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