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Article

Investigation of protein binding affinity in multimodal chromatographic systems using a homologous protein library.

Journal of chromatography. A - 8 Jan 2010

Chung Wai Keen, Hou Ying, Holstein Melissa, Freed Alexander, Makhatadze George I, Cramer Steven M

Abstract excerpt

A library of cold shock protein B mutant variants was employed to examine differences in protein binding behavior in ion exchange and multimodal chromatography. Single site mutations introduced at charged amino acids on the protein surface resulted in a homologous protein set with varying charge...

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Identifiers

PMID: 19732898
DOI: 10.1016/j.chroma.2009.08.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19732898-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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