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Article

Heat-sterilizable antibody mimics designed on the cold shock protein scaffold from hyperthermophile Thermotoga maritima.

Protein science : a publication of the Protein Society - 1 Jan 2025

Amesaka Hiroshi, Tachibana Marin, Hara Mizuho, Toya Shuntaro, Nakagawa Haruki, Matsumura Hiroyoshi, Hirata Azumi, Fujihashi Masahiro, Takano Kazufumi, Tanaka Shun-Ichi

Abstract excerpt

Antibodies and antibody mimics are extensively used in the pharmaceutical industry, where stringent safety standards are required. Implementing heat sterilization during or after the manufacturing process could help prevent contamination by viruses and bacteria. However, conventional antibodies and antibody mimics are not suitable for heat sterilization because they irreversibly denature at high temperatures. In...

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PMID: 39724358
DOI: 10.1002/pro.70018
PMCID: PMC11670304

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