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Article

Role of WNT/β-catenin signaling in rejuvenating myogenic differentiation of aged mesenchymal stem cells from cardiac patients.

The American journal of pathology - 1 Dec 2012

Brunt Keith R, Zhang Yuemei, Mihic Anton, Li Mingxi, Li Shu-Hong, Xue Phil, Zhang William, Basmaji Samir, Tsang Katherine, Weisel Richard D, Yau Terrence M, Li Ren-Ke

Abstract excerpt

Autologous stem cell therapy has not been as effective as forecasted from preclinical studies. Patient age was reported as an important contributing factor. The goal of this study was to uncover age-dependent mechanisms of stem cell dysfunction and to investigate possible means to restore the cellular function. Bone marrow mesenchymal stem cells (MSCs) were isolated from cardiovascular patients. Cell...

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Source

Identifiers

PMID: 23026201
DOI: 10.1016/j.ajpath.2012.08.021

Genes

CTNNB1
FOSL1
FZD6
FZD8
LRP6
SFRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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