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Article

The energetics of the acetylation switch in p53-mediated transcriptional activation.

Proteins - 1 Feb 2010

Eichenbaum Kenneth D, Rodríguez Yoel, Mezei Mihaly, Osman Roman

Abstract excerpt

Targeted therapeutic intervention in receptor-ligand interactions of p53-mediated tumor suppression can impact progression of disease, aging, and variation in genetic expression. Here, we conducted a number of molecular simulations, based on structures of p53 in complex with its transcriptional c...

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Topics

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Share to Acetylation
Share to CREB-Binding Protein
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation

Share to Thermodynamics

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 19731376
DOI: 10.1002/prot.22565
PMCID: PMC2882964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19731376-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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