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Article

The energetics of the acetylation switch in p53-mediated transcriptional activation.

Proteins - 1 Feb 2010

Eichenbaum Kenneth D, Rodríguez Yoel, Mezei Mihaly, Osman Roman

Abstract excerpt

Targeted therapeutic intervention in receptor-ligand interactions of p53-mediated tumor suppression can impact progression of disease, aging, and variation in genetic expression. Here, we conducted a number of molecular simulations, based on structures of p53 in complex with its transcriptional coactivating CBP bromodomain, determined by NMR spectroscopy, to investigate the energetics of the binding complex....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19731376
DOI: 10.1002/prot.22565
PMCID: PMC2882964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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