Article

Activation of PKR by a short-hairpin RNA

2024-05-10

Abstract excerpt

Recognition of viral infection often relies on the detection of double-stranded RNA (dsRNA), a process that is conserved in many different organisms. In mammals, proteins such as MDA5, RIG-I, OAS, and PKR detect viral dsRNA, but struggle to differentiate between viral and endogenous dsRNA. This study investigates an shRNA targeting DDX54’s potential to activate PKR, a key player in the immune response to dsRNA. Kn...

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Literature Corpus work: bb500e27-b874-514c-9695-b715277d9f10
DOI: 10.1101/2024.05.08.592371

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