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Article

Short interfering RNA confers intracellular antiviral immunity in human cells.

Nature - 25 Jul 2002

Gitlin Leonid, Karelsky Sveta, Andino Raul

Abstract excerpt

Gene silencing mediated by double-stranded RNA (dsRNA) is a sequence-specific, highly conserved mechanism in eukaryotes. In plants, it serves as an antiviral defence mechanism. Animal cells also possess this machinery but its specific function is unclear. Here we demonstrate that dsRNA can effectively protect human cells against infection by a rapidly replicating and highly cytolytic RNA virus. Pre-treatment of...

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Identifiers

PMID: 12087357
DOI: 10.1038/nature00873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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