Article
Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma.
Pediatric pulmonology - 1 Oct 2009
Thomou Christina, Paraskakis Emmanouil, Neofytou Eirini, Kalmanti Maria, Siafakas Nikolaos M, Tzortzaki Eleni G
Abstract excerpt
OBJECTIVES: High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS: The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOLOGY: DNA was extracted from sputum and blood cells of 27 children (10.8 +/- 2.5 years) with mild...
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