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Article

Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells

2 Sept 2009

Abstract excerpt

Induced pluripotent stem cells (iPSCs) have been derived at low frequencies from different cell types through ectopic expression of the transcription factors Oct4 and Sox2, combined with either Klf4 and c-Myc or Lin28 and Nanog. In order to generate iPSCs more effectively, it will be crucial to identify somatic cells that are easily accessible and possibly require fewer factors for conversion into iPSCs. Here, we...

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PMID: 19723802
DOI: 10.1242/jcs.054783

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