Article
Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma.
Molecular carcinogenesis - 1 Jan 2010
Bakkar Ashraf A, Allory Yves, Iwatsubo Yuriko, de Medina Sixtina Gil Diez, Maille Pascale, Khreich Nathalie, Riou Audrey, Leroy Karen, Vordos Dimitrios, Abbou Claude C, Andujar Pascal, Billebaud Thierry, Chammings Soizick, Conso Françoise, De La Taille Alexandre, Fontaine Eric, Gattegno Bernard, Ravery Vincent, Sibony Mathilde, Radvanyi François, Chopin Dominique K, Pairon Jean-Claude
Abstract excerpt
Occupational exposure to polycyclic aromatic hydrocarbons (PAH) is associated with an increased risk of urothelial carcinoma (UC). FGFR3 is found mutated in about 70% of Ta tumors, which represent the major group at diagnosis. The influence of PAH on FGFR3 mutations and whether it is related to t...
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