Article
Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Carcinogenesis - 1 Jan 2002
Alguacil Juan, Porta Miquel, Malats Núria, Kauppinen Timo, Kogevinas Manolis, Benavides Fernando G, Partanen Timo, Carrato Alfredo
Abstract excerpt
Occupational exposure to hydrocarbon solvents has been found to be associated with an increased risk of exocrine pancreatic cancer (EPC), the human tumor with the highest prevalence of K-ras mutations. Ras genes are critical DNA targets for chemical carcinogens. We analysed the relationship between past occupational exposure to hydrocarbon solvents and mutations in codon 12 of the K-ras gene in 107 incident cases...
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