Article
Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens.
Carcinogenesis - 1 Jan 2005
Wallerand Hervé, Bakkar Ashraf A, de Medina Sixtina Gil Diez, Pairon Jean-Claude, Yang Yu-Ching, Vordos Dimitri, Bittard Hugues, Fauconnet Sylvie, Kouyoumdjian Jean-Claude, Jaurand Marie-Claude, Zhang Zuo-Feng, Radvanyi François, Thiery Jean-Paul, Chopin Dominique K
Abstract excerpt
Smoking is a major risk factor for urothelial cell carcinoma of the bladder (UCC). Mutations in the FGFR3 and TP53 genes have been shown to define two distinct pathways in superficial papillary and invasive UCC disease, respectively. We investigated the relationship between smoking and these mutations by means of denaturing high performance liquid chromatography and sequencing for 110 primary UCC of the bladder....
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